Negative regulation of lymphocyte activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAHD1, EPCAM, and DCK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte activation activity versus FAHD1 in STOMACH (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAHD1 →	+1.115	+0.360	.002	.003	3	7
BONE	EPCAM →	-1.880	-0.399	<.001	.001	3	6
CNS	DCK →	+0.751	+0.348	.001	.001	3	5
BLOOD_Lymphoma	ANXA5 →	+1.877	+0.275	<.001	<.001	3	5
BLOOD_Lymphoma	KDF1 →	-0.310	-0.187	.004	<.001	3	5
OESOPHAGUS	PIP4K2A →	+1.026	+0.382	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051250 vs FAHD1 — STOMACH

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