Establishment of RNA localization

Across TCGA patient cohorts, RNA activity of the Establishment of RNA localization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM28, SMC3, and ADNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of RNA localization activity versus TRIM28 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM28 →	+0.294	+0.085	<.001	.001	3	6
LSCC	SMC3 →	+0.246	+0.045	.002	.003	3	6
LSCC	ADNP →	+0.354	+0.057	<.001	<.001	3	6
LSCC	THOC1 →	+0.177	+0.035	.002	<.001	3	6
LSCC	LUC7L3 →	+0.191	+0.037	<.001	<.001	3	6
LSCC	MSH2 →	+0.440	+0.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051236 vs TRIM28 — HNSC

Explore this scatter interactively →