Establishment of RNA localization

Across TCGA cell cohorts, RNA activity of the Establishment of RNA localization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXN2, FIGNL1, and VSIG10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TXN2 grouped by Establishment of RNA localization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TXN2 →	+0.609	+0.153	<.001	<.001	3	4
LUNG_NSCLC_LUAD	FIGNL1 →	-0.510	-0.101	.008	.006	3	4
LUNG_NSCLC_LUAD	VSIG10 →	-0.696	-0.079	.001	.004	3	4
SOFT_TISSUE	TENT5B →	-1.791	-0.172	.004	.003	3	4
KIDNEY	USP10 →	-0.717	-0.190	.006	<.001	3	4
BLOOD_Leukemia	RNASET2 →	+2.012	+0.145	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TXN2 by Establishment of RNA localization activity — OESOPHAGUS

Explore this box plot interactively →