Establishment of RNA localization

Across TCGA cell cohorts, RNA activity of the Establishment of RNA localization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDELR3, TMEFF1, and DLK2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of RNA localization activity versus KDELR3 in CNS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KDELR3 →	-2.030	-0.252	.001	.002	3	7
LUNG_SCLC	TMEFF1 →	+1.965	+0.182	<.001	<.001	3	7
BREAST	DLK2 →	+1.260	+0.155	<.001	.001	3	7
LUNG_NSCLC_LUAD	TMED3 →	-0.867	-0.191	<.001	.001	3	6
CNS	ZNF286B →	+0.645	+0.162	.001	.005	1	8
BREAST	TRPM4 →	-1.365	-0.189	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051236 vs KDELR3 — CNS

Explore this scatter interactively →