Spindle elongation

Across TCGA cell cohorts, RNA activity of the Spindle elongation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMG9, EXPH5, and CEP20, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMG9 grouped by Spindle elongation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMG9 →	+1.143	+0.218	<.001	.004	2	6
URINARY_TRACT	EXPH5 →	+2.159	+0.238	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CEP20 →	-1.218	-0.209	.002	<.001	3	4
LUNG_NSCLC_LUSC	MLLT10 →	-0.585	-0.120	.009	.007	3	4
SKIN	CACYBP →	-0.771	-0.127	.008	.006	3	4
SKIN	SLC25A19 →	-0.798	-0.128	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMG9 by Spindle elongation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →