Spindle elongation

Across TCGA cell cohorts, RNA activity of the Spindle elongation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGT1, GALNT3, and THEM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle elongation activity versus GGT1 in BLOOD_Lymphoma (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GGT1 →	-2.295	-1.009	.003	.006	3	5
BREAST	GALNT3 →	-1.939	-0.997	.003	.005	3	5
BLOOD_Leukemia	THEM4 →	-1.865	-1.192	<.001	<.001	3	5
BLOOD_Leukemia	NUSAP1 →	+0.919	+1.396	<.001	<.001	3	5
BLOOD_Leukemia	BIRC5 →	+0.653	+1.229	<.001	<.001	3	5
BLOOD_Leukemia	SETD1A →	+0.532	+1.358	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051231 vs GGT1 — BLOOD_Lymphoma

Explore this scatter interactively →