Spindle assembly

Across TCGA cell cohorts, RNA activity of the Spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXL8, H4-16, and UTS2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXL8 grouped by Spindle assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FBXL8 →	+0.995	+0.106	<.001	<.001	3	5
PANCREAS	H4-16 →	+0.875	+0.180	.002	<.001	3	5
OESOPHAGUS	UTS2B →	+0.294	+0.140	.001	<.001	3	4
OESOPHAGUS	CHPF2 →	+1.024	+0.170	.001	.001	3	4
BLOOD_Myeloma	JUNB →	+1.456	+0.233	.005	.001	3	4
BONE	CASP4 →	+2.927	+0.219	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXL8 by Spindle assembly activity — BREAST

Explore this box plot interactively →