Cartilage development

Across TCGA cell cohorts, RNA activity of the Cartilage development pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BUB3, SIRPD, and GRK6P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BUB3 grouped by Cartilage development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BUB3 →	-0.347	-0.061	.001	.004	3	5
OESOPHAGUS	SIRPD →	+0.185	+0.045	<.001	.002	3	5
PANCREAS	GRK6P1 →	+0.247	+0.075	.001	.001	3	5
PANCREAS	PPEF1 →	-0.316	-0.091	.001	<.001	3	4
OVARY	CPLANE2 →	-0.238	-0.067	.002	.001	2	5
OVARY	LCN12 →	-0.303	-0.068	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BUB3 by Cartilage development activity — CNS

Explore this box plot interactively →