Cartilage development

Across TCGA cell cohorts, RNA activity of the Cartilage development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD44, ZNF197, and MRPS35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cartilage development activity versus CD44 in BONE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CD44 →	+5.426	+1.958	.007	<.001	3	5
OESOPHAGUS	ZNF197 →	-0.948	-1.013	<.001	.002	3	4
OESOPHAGUS	MRPS35 →	-0.652	-1.338	.001	<.001	3	4
BLOOD_Myeloma	VWA8 →	-0.853	-1.171	<.001	.001	3	4
BLOOD_Myeloma	UBA7 →	+1.924	+1.226	.001	.007	3	4
BREAST	EAF1 →	-0.865	-1.055	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051216 vs CD44 — BONE

Explore this scatter interactively →