Protein insertion into membrane

Across TCGA patient cohorts, RNA activity of the Protein insertion into membrane pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT10B, TIGD1, and MRPL20-DT, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into membrane activity versus TRMT10B in UVM (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	TRMT10B →	+0.833	+0.034	<.001	<.001	3	27
UVM	TIGD1 →	+0.907	+0.032	<.001	<.001	3	27
UVM	MRPL20-DT →	+0.796	+0.031	<.001	<.001	3	27
UVM	MTERF2 →	+1.004	+0.034	<.001	<.001	3	26
KIRC	GPS2 →	+0.997	+0.046	<.001	<.001	3	26
UVM	ZGRF1 →	+0.631	+0.037	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051205 vs TRMT10B — UVM

Explore this scatter interactively →