Prosthetic group metabolic process

Across TCGA patient cohorts, RNA activity of the Prosthetic group metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPHN, SURF4, and PTPN14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prosthetic group metabolic process activity versus GPHN in CCRCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GPHN →	+0.461	+0.140	<.001	<.001	3	5
BRCA	SURF4 →	-0.401	-0.288	<.001	.003	3	4
BRCA	PTPN14 →	-0.803	-0.307	<.001	.001	3	4
GBM	COLGALT1 →	-0.396	-0.164	<.001	<.001	3	4
GBM	BCL2A1 →	-0.922	-0.176	.006	.001	3	4
GBM	FCGR2A →	-0.703	-0.140	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051189 vs GPHN — CCRCC

Explore this scatter interactively →