Prosthetic group metabolic process

Across TCGA cell cohorts, RNA activity of the Prosthetic group metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZGLP1, TERB1, and TFAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZGLP1 grouped by Prosthetic group metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZGLP1 →	+0.943	+0.214	.006	.001	3	3
KIDNEY	TERB1 →	-0.077	-1.486	.005	.001	3	3
LUNG_SCLC	TFAM →	+0.911	+0.302	.001	.002	3	3
LARGE_INTESTINE	CEP57 →	+0.846	+1.134	<.001	.002	3	3
PANCREAS	TCL1A →	+0.090	+1.919	.001	<.001	2	4
OVARY	CLDN7 →	-3.282	-1.300	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZGLP1 by Prosthetic group metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →