Prosthetic group metabolic process

Across TCGA cell cohorts, RNA activity of the Prosthetic group metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGH, DLG1, and ZNF117, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prosthetic group metabolic process activity versus PIGH in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PIGH →	+0.757	+1.103	<.001	<.001	2	5
BLOOD_Lymphoma	DLG1 →	-0.834	-1.113	.003	.002	3	4
LUNG_SCLC	ZNF117 →	-2.083	-1.272	<.001	.002	3	3
URINARY_TRACT	WHAMM →	-0.945	-1.414	.001	<.001	3	3
SKIN	TGIF1 →	+0.745	+0.921	.002	.002	3	3
BLOOD_Lymphoma	LHB →	+1.054	+0.889	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051189 vs PIGH — PANCREAS

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