Meiotic sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Meiotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTBP, DDX11-AS1, and THAP5P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic sister chromatid cohesion activity versus MTBP in GBM (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MTBP →	+0.528	+0.525	.003	.002	3	4
GBM	DDX11-AS1 →	+0.447	+0.498	<.001	<.001	3	4
HNSC	THAP5P1 →	+0.825	+0.612	<.001	<.001	3	3
GBM	GALNT6 →	-0.552	-0.382	<.001	.001	3	3
GBM	ATAD5 →	+0.682	+0.489	.004	.004	3	3
GBM	LINC02585 →	+0.540	+0.378	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051177 vs MTBP — GBM

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