Meiotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Meiotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAIAP2, ITGA3, and COPB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAIAP2 grouped by Meiotic sister chromatid cohesion-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BAIAP2 →	+1.124	+0.213	.008	.007	3	5
STOMACH	ITGA3 →	+3.191	+0.231	<.001	.005	3	4
LARGE_INTESTINE	COPB2 →	-0.615	-0.198	.003	.006	3	4
LIVER	WWP1 →	-0.871	-0.308	.005	.001	2	5
BONE	BATF3 →	+1.501	+0.313	<.001	<.001	3	4
LARGE_INTESTINE	FAM122C →	-0.830	-0.216	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAIAP2 by Meiotic sister chromatid cohesion activity — KIDNEY

Explore this box plot interactively →