Positive regulation of sulfur metabolic process

pathway activity — cross-omics
GO:0051176Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of sulfur metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD300A, EIF4BP6, and SCARF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCD300A →-1.137-0.166<.001<.00134
LUADEIF4BP6 →+0.510+0.134<.001.00234
PDACSCARF1 →-0.294-0.403.006.00734
GBMCYTH1 →-0.336-0.365.006.00533
GBMAGTPBP1 →-0.529-0.406<.001.00433
HNSCSLC17A5 →-0.473-0.193.001.00124
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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