Import into nucleus

Across TCGA patient cohorts, RNA activity of the Import into nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SBSPON, CLIC2, and PHLDB1_S419, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Import into nucleus activity versus SBSPON in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SBSPON →	+0.783	+0.025	<.001	<.001	3	6
GBM	CLIC2 →	+0.404	+0.029	.006	.001	3	6
PDAC	PHLDB1_S419 →	+0.453	+0.027	.006	.002	3	6
HNSC	SEPTIN4_S432 →	+0.551	+0.063	<.001	.001	3	5
HNSC	CSNK1A1 →	-0.669	-0.079	<.001	.001	3	5
BRCA	VWF →	+0.233	+0.018	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051170 vs SBSPON — BRCA

Explore this scatter interactively →