Import into nucleus

Across TCGA cell cohorts, RNA activity of the Import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR46, DBF4B, and PRR3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Import into nucleus activity versus WDR46 in OVARY (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	WDR46 →	+0.647	+0.208	.001	.001	2	7
OVARY	DBF4B →	+0.970	+0.241	.009	.004	3	6
OVARY	PRR3 →	+0.897	+0.200	.002	.003	3	6
BREAST	ICA1 →	-2.286	-0.222	<.001	<.001	3	6
OVARY	NUP93 →	+0.812	+0.205	<.001	<.001	3	5
OVARY	IL27RA →	+1.727	+0.244	.006	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051170 vs WDR46 — OVARY

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