Xylulose 5-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Xylulose 5-phosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORD, ECHS1, and ETFB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xylulose 5-phosphate metabolic process activity versus SORD in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SORD →	+0.742	+0.078	<.001	<.001	3	8
PDAC	ECHS1 →	+0.372	+0.049	<.001	<.001	3	6
PDAC	ETFB →	+0.321	+0.040	<.001	<.001	3	6
HNSC	AKAP1 →	+0.253	+0.056	.001	.001	3	6
LSCC	STK17A →	-0.348	-0.051	<.001	<.001	3	6
UCEC	L2HGDH →	+0.389	+0.097	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051167 vs SORD — OV

Explore this scatter interactively →