Xylulose 5-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Xylulose 5-phosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYL1, TKT, and DCXR, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRYL1 grouped by Xylulose 5-phosphate metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CRYL1 →	-0.607	-1.865	<.001	.009	2	12
OVARY	TKT →	-0.223	-0.271	.001	.002	3	5
LARGE_INTESTINE	DCXR →	-0.232	-0.246	<.001	<.001	3	5
SKIN	GLT8D1 →	+0.255	+1.085	<.001	.001	3	4
CNS	SLC19A1 →	+0.124	+0.285	<.001	.008	3	4
UPPER_AERODIGESTIVE_TRACT	CD79A →	+0.168	+0.511	.004	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRYL1 by Xylulose 5-phosphate metabolic process activity — URINARY_TRACT

Explore this box plot interactively →