Xylulose 5-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Xylulose 5-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SORD, AXL, and IKBIP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xylulose 5-phosphate metabolic process activity versus SORD in BONE (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SORD →	+2.718	+0.480	<.001	<.001	3	8
BONE	AXL →	-4.638	-0.366	.002	.005	3	7
LUNG_SCLC	IKBIP →	-1.598	-0.252	.004	.003	2	7
LARGE_INTESTINE	RGS16 →	+1.398	+0.292	<.001	<.001	3	6
STOMACH	TNFRSF9 →	-0.461	-0.542	.005	<.001	3	6
STOMACH	TTLL12 →	+0.920	+0.312	.005	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051167 vs SORD — BONE

Explore this scatter interactively →