Glucose 6-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Glucose 6-phosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are G6PD, CES1, and CYBA_T147, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose 6-phosphate metabolic process activity versus G6PD in LSCC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	G6PD →	+0.605	+0.043	<.001	.003	3	6
UCEC	CES1 →	+0.866	+0.074	<.001	.001	3	5
CCRCC	CYBA_T147 →	+0.622	+0.060	.001	<.001	3	5
CCRCC	MAP1B_S1772 →	+0.708	+0.057	<.001	.004	2	6
LSCC	TXNRD1 →	+0.673	+0.052	<.001	<.001	3	5
GBM	MAP3K8_S141 →	+0.547	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051156 vs G6PD — LSCC

Explore this scatter interactively →