Glucose 6-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Glucose 6-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIG1, SH3TC1, and AUNIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose 6-phosphate metabolic process activity versus LIG1 in LUAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LIG1 →	-0.398	-0.148	.004	.005	3	3
LUAD	SH3TC1 →	+0.400	+0.164	.001	.005	3	3
LUAD	AUNIP →	-0.683	-0.146	.001	.005	3	3
LUAD	SAE1 →	-0.344	-0.207	<.001	<.001	3	3
LUAD	COX6C →	-0.382	-0.132	.004	.008	3	3
LUAD	PA2G4 →	-0.320	-0.129	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051156 vs LIG1 — LUAD

Explore this scatter interactively →