Glucose 6-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Glucose 6-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBR1, G6PD, and PGD, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose 6-phosphate metabolic process activity versus CBR1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CBR1 →	+0.986	+0.313	.003	.002	3	8
LUNG_NSCLC_LUAD	G6PD →	+1.935	+0.337	<.001	<.001	3	8
LUNG_NSCLC_LUAD	PGD →	+1.666	+0.304	<.001	<.001	3	8
PANCREAS	HK1 →	+1.313	+0.282	.006	.003	3	8
BLOOD_Lymphoma	SOD1 →	+1.139	+0.171	.004	.003	3	7
UPPER_AERODIGESTIVE_TRACT	GSR →	+1.247	+0.374	.007	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051156 vs CBR1 — UPPER_AERODIGESTIVE_TRACT

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