Positive regulation of striated muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of striated muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC3, SVEP1, and IFFO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of striated muscle cell differentiation activity versus AOC3 in LUAD (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AOC3 →	+0.540	+0.131	.003	.005	3	5
HNSC	SVEP1 →	+0.782	+0.375	<.001	.004	3	5
BRCA	IFFO1 →	+0.991	+1.055	<.001	<.001	3	4
BRCA	SERPINF1 →	+1.187	+1.041	<.001	<.001	3	4
BRCA	VENTX →	+0.771	+0.909	<.001	<.001	3	4
LUAD	A2M →	+0.510	+0.122	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051155 vs AOC3 — LUAD

Explore this scatter interactively →