Positive regulation of striated muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of striated muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP14, KLF15, and GPR68, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of striated muscle cell differentiation activity versus MMP14 in STOMACH (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MMP14 →	+3.915	+1.029	.001	.009	2	9
BONE	KLF15 →	-1.695	-1.555	.001	.002	3	5
CNS	GPR68 →	+1.198	+0.959	.008	.002	3	5
LUNG_SCLC	SLC35A5 →	+0.811	+1.336	.001	<.001	3	5
LUNG_SCLC	GSK3B →	+0.546	+1.012	.003	<.001	2	6
BONE	ARL4C →	+2.297	+1.392	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051155 vs MMP14 — STOMACH

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