Negative regulation of striated muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of striated muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABI3BP, FKBP7, and TNS2_S120, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle cell differentiation activity versus ABI3BP in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABI3BP →	+0.751	+0.033	.004	<.001	2	8
BRCA	FKBP7 →	+0.422	+0.026	<.001	<.001	3	7
LSCC	TNS2_S120 →	+0.650	+0.046	<.001	<.001	3	6
CCRCC	C1S →	+0.462	+0.027	<.001	.006	3	6
CCRCC	CLEC3B →	+0.687	+0.034	<.001	<.001	3	6
BRCA	CLIC2 →	+0.461	+0.035	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051154 vs ABI3BP — BRCA

Explore this scatter interactively →