Negative regulation of striated muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of striated muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HASPIN, RPL12P11, and H2BC11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle cell differentiation activity versus HASPIN in LUAD (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HASPIN →	+0.750	+0.457	<.001	<.001	3	5
GBM	RPL12P11 →	+0.443	+0.536	.001	.007	3	5
LSCC	H2BC11 →	+0.655	+0.311	.002	.002	3	4
GBM	H2BC5 →	+0.639	+0.701	.001	<.001	3	4
LSCC	C19orf48 →	+0.648	+0.314	.001	.009	3	4
LUAD	SAPCD2 →	+1.169	+0.431	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051154 vs HASPIN — LUAD

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