Negative regulation of striated muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of striated muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN20, TANGO6, and RPS11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN20 grouped by Negative regulation of striated muscle cell differentiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN20 →	-0.376	-0.858	.004	.009	3	4
SOFT_TISSUE	TANGO6 →	-0.576	-0.752	.004	.008	3	4
UPPER_AERODIGESTIVE_TRACT	RPS11 →	+0.720	+0.249	<.001	.001	3	4
SOFT_TISSUE	TMEM234 →	-1.409	-0.453	<.001	.001	3	3
PANCREAS	ZNF224 →	-0.787	-0.895	.002	.006	3	3
SOFT_TISSUE	ITGB3BP →	+0.789	+0.773	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN20 by Negative regulation of striated muscle cell differentiation activity — PANCREAS

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