Negative regulation of striated muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of striated muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, ADAM11, and CARD6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle cell differentiation activity versus G6PD in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	G6PD →	+2.082	+0.594	<.001	.001	3	8
URINARY_TRACT	ADAM11 →	-0.995	-0.307	.009	.001	3	8
SOFT_TISSUE	CARD6 →	+1.773	+0.783	<.001	.005	3	8
LARGE_INTESTINE	LRRC8C →	-1.114	-0.382	.001	.008	3	6
LUNG_NSCLC_LUAD	AKR1C3 →	+3.738	+0.571	.001	.004	3	6
STOMACH	SDCBP2 →	+3.411	+0.416	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051154 vs G6PD — BREAST

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