Negative regulation of striated muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of striated muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are G6PD, SAP30BP, and GSTK1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle cell differentiation activity versus G6PD in LUNG_NSCLC_LUSC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	G6PD →	+3.785	+0.531	.001	.004	3	12
BONE	SAP30BP →	-0.992	-1.043	<.001	<.001	3	8
LUNG_NSCLC_LUSC	GSTK1 →	+1.435	+0.463	.003	.002	3	7
STOMACH	CBX1 →	-1.336	-0.431	<.001	<.001	3	7
OVARY	SOX6 →	+1.703	+0.674	<.001	.003	3	7
BONE	MCM6 →	-1.068	-0.553	.002	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051154 vs G6PD — LUNG_NSCLC_LUSC

Explore this scatter interactively →