Regulation of striated muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of striated muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NES_S768, HSPA12B, and OLFML1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of striated muscle cell differentiation activity versus NES_S768 in HNSC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NES_S768 →	+0.946	+0.039	<.001	.001	3	8
OV	HSPA12B →	+0.377	+0.023	<.001	.001	3	8
BRCA	OLFML1 →	+1.003	+0.035	<.001	<.001	3	8
LSCC	FMNL3 →	+0.382	+0.048	<.001	<.001	3	8
BRCA	RSU1 →	+0.345	+0.029	<.001	<.001	3	7
CCRCC	ASPN →	+0.688	+0.031	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051153 vs NES_S768 — HNSC

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