Regulation of striated muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of striated muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX1, KBTBD7, and ZSCAN29, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDX1 grouped by Regulation of striated muscle cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRDX1 →	+1.429	+0.273	.003	.001	3	3
LUNG_NSCLC_LUSC	KBTBD7 →	+1.018	+0.303	.004	.005	3	3
LUNG_NSCLC_LUSC	ZSCAN29 →	+0.671	+0.281	.009	.001	3	3
LUNG_NSCLC_LUSC	GPR39 →	-2.025	-0.267	<.001	.001	3	3
LUNG_NSCLC_LUSC	ME1 →	+1.995	+0.279	.001	.002	3	3
URINARY_TRACT	FHL2 →	-2.326	-0.275	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDX1 by Regulation of striated muscle cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →