Regulation of striated muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of striated muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX1, G6PD, and CEACAM5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of striated muscle cell differentiation activity versus CBX1 in LIVER (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CBX1 →	-1.155	-0.308	.002	.003	3	5
LIVER	G6PD →	+2.153	+0.289	.007	.008	1	7
LARGE_INTESTINE	CEACAM5 →	+3.788	+0.561	.001	.006	3	5
LUNG_NSCLC_LUAD	STK25 →	-0.732	-0.499	<.001	.002	3	5
LARGE_INTESTINE	TMEM237 →	-0.971	-0.704	.001	.002	3	5
LARGE_INTESTINE	ZNF286A →	-1.137	-0.536	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051153 vs CBX1 — LIVER

Explore this scatter interactively →