Positive regulation of smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPAT4, SLC9B2, and NAV3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPAT4 grouped by Positive regulation of smooth muscle cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPAT4 →	-0.881	-0.378	.003	.004	3	6
BREAST	SLC9B2 →	-1.335	-0.749	<.001	.002	3	5
CNS	NAV3 →	-1.725	-0.812	.001	.009	3	5
BLOOD_Leukemia	STT3A →	-0.712	-0.953	<.001	.004	3	5
BLOOD_Leukemia	TBRG1 →	-0.953	-1.650	<.001	<.001	3	4
BREAST	H2BC6 →	+0.684	+0.857	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPAT4 by Positive regulation of smooth muscle cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →