Positive regulation of smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM72A, DPM2, and SRGAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell differentiation activity versus FAM72A in LARGE_INTESTINE (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM72A →	-0.967	-1.002	.002	.003	3	6
BREAST	DPM2 →	-0.443	-0.449	.004	.004	3	5
OVARY	SRGAP2 →	-0.881	-0.647	.001	.005	3	5
BREAST	COQ4 →	-0.580	-0.532	.003	.006	3	4
BREAST	SLC25A10 →	-1.414	-0.647	<.001	.002	3	4
LARGE_INTESTINE	CCP110 →	-0.821	-0.871	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051152 vs FAM72A — LARGE_INTESTINE

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