Negative regulation of smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, CCR7, and TRAJ1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell differentiation activity versus IL2RB in GBM (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL2RB →	+0.828	+0.422	<.001	<.001	3	5
HNSC	CCR7 →	+0.895	+0.738	<.001	<.001	3	4
HNSC	TRAJ1 →	+1.583	+0.784	<.001	<.001	3	4
HNSC	COPDA1 →	+0.831	+0.721	<.001	<.001	3	4
HNSC	P2RY10 →	+0.790	+0.686	.002	.003	3	4
UCEC	ZC3H12D →	+0.578	+0.816	.002	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051151 vs IL2RB — GBM

Explore this scatter interactively →