Negative regulation of smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA11, PERP, and HGD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell differentiation activity versus ANXA11 in LUNG_SCLC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA11 →	-1.131	-0.788	.006	.006	3	5
BLOOD_Lymphoma	PERP →	-3.527	-0.817	<.001	.004	3	5
BLOOD_Lymphoma	HGD →	-0.222	-0.875	<.001	.004	3	5
BONE	SEC11A →	-1.021	-1.320	.002	.002	3	5
BONE	PXDC1 →	-2.935	-1.630	.004	<.001	3	5
BLOOD_Lymphoma	PRDM1 →	-2.755	-0.871	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051151 vs ANXA11 — LUNG_SCLC

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