Regulation of smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of smooth muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARVA, TNS2_S120, and SNX9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of smooth muscle cell differentiation activity versus PARVA in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PARVA →	+0.442	+0.053	<.001	<.001	3	9
UCEC	TNS2_S120 →	+0.521	+0.047	<.001	.002	3	8
LSCC	SNX9 →	+0.312	+0.063	<.001	<.001	3	8
LUAD	CLPX →	-0.313	-0.053	<.001	<.001	3	8
BRCA	HSPG2 →	+0.554	+0.041	<.001	<.001	3	8
UCEC	KANK2 →	+0.586	+0.051	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051150 vs PARVA — UCEC

Explore this scatter interactively →