Regulation of smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADNP2, CAPS, and SERPING1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADNP2 grouped by Regulation of smooth muscle cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADNP2 →	+0.458	+0.489	.007	.007	3	3
STOMACH	CAPS →	-2.070	-0.364	.004	.003	3	3
KIDNEY	SERPING1 →	-2.366	-0.967	.001	.001	3	3
SKIN	ABCC3 →	-1.624	-0.235	<.001	.002	3	3
SKIN	PDE10A →	+1.565	+0.347	.002	.009	3	3
SOFT_TISSUE	F2RL1 →	-5.513	-1.107	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADNP2 by Regulation of smooth muscle cell differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →