Positive regulation of muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A4, METTL16, and RPAIN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A4 grouped by Positive regulation of muscle cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC22A4 →	-1.963	-1.039	.003	.008	3	4
BLOOD_Leukemia	METTL16 →	+0.776	+1.113	<.001	.005	3	4
BLOOD_Leukemia	RPAIN →	+0.615	+0.815	.001	.004	3	4
BLOOD_Leukemia	PRPSAP2 →	+0.697	+0.843	.004	.003	2	5
UPPER_AERODIGESTIVE_TRACT	RHD →	-0.198	-1.197	.005	.005	3	4
SOFT_TISSUE	SERINC3 →	-1.041	-0.807	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A4 by Positive regulation of muscle cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →