Positive regulation of muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB6A, SPHK2, and CDC37, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB6A grouped by Positive regulation of muscle cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RAB6A →	-0.258	-0.051	.002	.008	3	5
STOMACH	SPHK2 →	-0.141	-0.118	<.001	<.001	3	5
BREAST	CDC37 →	-0.509	-0.109	.002	.004	3	4
BLOOD_Leukemia	PANK1 →	-0.180	-0.101	<.001	.001	3	4
LUNG_NSCLC_LUAD	UGT2B7 →	-0.165	-0.067	.002	.002	3	4
BREAST	ITGA1 →	+0.163	+0.104	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB6A by Positive regulation of muscle cell differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →