Positive regulation of muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTR9, TMEM150C, and SPOPL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle cell differentiation activity versus CTR9 in BLOOD_Lymphoma (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTR9 →	-1.029	-0.961	.003	.004	3	4
BREAST	TMEM150C →	-1.732	-0.919	.002	.001	3	4
BREAST	SPOPL →	-0.823	-0.754	<.001	.003	3	4
URINARY_TRACT	FBN2 →	+4.892	+0.343	.002	.002	3	4
SKIN	NDUFS7 →	-0.760	-1.085	.008	.002	3	4
BREAST	NPDC1 →	-1.349	-0.739	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051149 vs CTR9 — BLOOD_Lymphoma

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