Negative regulation of muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PASK, E2F2, and CCNA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle cell differentiation activity versus PASK in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PASK →	+0.566	+0.660	<.001	.001	3	5
LUAD	E2F2 →	+0.739	+0.736	<.001	<.001	3	4
UCEC	CCNA2 →	+0.894	+0.735	<.001	<.001	3	4
UCEC	FBXW5 →	+1.288	+0.697	.003	<.001	3	4
LUAD	SEPTIN4 →	-0.216	-0.409	.008	.004	3	4
LUAD	MCM6 →	+0.782	+0.689	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051148 vs PASK — UCEC

Explore this scatter interactively →