Negative regulation of muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4C, STX2, and DZIP1L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle cell differentiation activity versus SEMA4C in BLOOD_Lymphoma (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SEMA4C →	-2.041	-0.266	.001	<.001	3	8
OVARY	STX2 →	-1.516	-0.243	.001	.009	3	7
BREAST	DZIP1L →	-1.503	-0.286	<.001	<.001	3	7
LARGE_INTESTINE	MED1 →	-0.670	-0.193	<.001	.003	3	7
LUNG_NSCLC_LUAD	C1orf216 →	-0.891	-0.286	.002	<.001	3	7
BLOOD_Lymphoma	SLC26A10 →	-1.714	-0.321	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051148 vs SEMA4C — BLOOD_Lymphoma

Explore this scatter interactively →