Regulation of muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of muscle cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAM5, SERPINI2, and OR2W3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGAM5 grouped by Regulation of muscle cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PGAM5 →	-0.175	-0.066	<.001	.009	3	4
LUNG_NSCLC_LUAD	SERPINI2 →	+0.119	+0.030	.005	.006	3	4
BREAST	OR2W3 →	+0.151	+0.058	.002	.003	3	4
LIVER	UBTF →	-0.193	-0.074	.003	<.001	3	4
LIVER	OR1D5 →	+0.193	+0.069	<.001	<.001	3	4
KIDNEY	FDPS →	-0.279	-0.049	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGAM5 by Regulation of muscle cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →