Regulation of muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D32, RAG2, and IRAK1BP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle cell differentiation activity versus TBC1D32 in BLOOD_Myeloma (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TBC1D32 →	-0.974	-0.166	.005	.008	3	5
OESOPHAGUS	RAG2 →	+0.180	+0.243	.001	.001	3	5
OVARY	IRAK1BP1 →	-0.703	-0.231	<.001	<.001	3	5
SOFT_TISSUE	VEGFC →	+4.590	+0.239	<.001	.001	3	5
SKIN	GPR157 →	-1.250	-0.256	.005	.001	3	5
UPPER_AERODIGESTIVE_TRACT	NEO1 →	-1.232	-0.242	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051147 vs TBC1D32 — BLOOD_Myeloma

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