Smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX6B1P5, SELENOI, and AKR1C7P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle cell differentiation activity versus COX6B1P5 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COX6B1P5 →	+0.489	+0.616	.007	.006	3	3
LSCC	SELENOI →	-0.525	-0.511	.001	.004	3	3
LSCC	AKR1C7P →	-1.185	-0.468	.002	.009	3	3
LSCC	LINC02762 →	-0.481	-0.562	.002	.001	3	3
COAD	CYYR1-AS1 →	+0.022	+0.391	.003	.001	3	3
UCEC	RFTN1 →	+0.459	+0.409	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051145 vs COX6B1P5 — BRCA

Explore this scatter interactively →