Smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM3, PRPS1, and ZDHHC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCM3 grouped by Smooth muscle cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MCM3 →	-0.802	-1.219	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PRPS1 →	-1.273	-1.192	.008	.002	3	4
STOMACH	ZDHHC2 →	-2.278	-1.123	.006	.003	3	4
LUNG_SCLC	FUCA2 →	-2.155	-0.793	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	BNIP3L →	-1.264	-1.468	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	STARD13 →	-1.103	-1.543	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCM3 by Smooth muscle cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →