Smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Smooth muscle cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRB14, OLFML3, and RTL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRB14 grouped by Smooth muscle cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GRB14 →	-0.217	-0.085	.001	.003	3	4
OESOPHAGUS	OLFML3 →	+0.332	+0.215	.001	.005	3	4
OESOPHAGUS	RTL6 →	-0.153	-0.208	.002	.001	3	4
BLOOD_Myeloma	BAIAP2L1 →	-0.210	-0.107	.002	<.001	3	4
LUNG_SCLC	FLNB →	+0.361	+0.144	<.001	.001	3	4
LUNG_SCLC	VCAN →	+0.203	+0.140	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRB14 by Smooth muscle cell differentiation activity — BREAST

Explore this box plot interactively →